Diretic Tablet (Furosemide 20mg + Spironolactone 50mg) belongs to the class of medications known as 'diuretics' (water pills), which aid in the removal of excess water from the body. Aside from that, it keeps the potassium level in the circulation stable and prevents hypertension (high blood pressure caused by edema (fluid retention). Oedema, also known as fluid overload, is linked to pulmonary hypertension (high blood pressure in the lungs) or heart failure (irregular heart pumping). Shortness of breath, chest discomfort (angina), irregular heart rhythms (arrhythmia), and swelling in other parts of the hands or belly are the most common symptoms of edema.
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Diretic Tablet is a combination medication that contains two active ingredients: Spironolactone and Furosemide. It is commonly used in the treatment of various conditions, including:
Overall, Diretic Tablet helps to alleviate fluid retention and associated symptoms by increasing urine production and enhancing the excretion of water and sodium from the body. It is important to note that the use of this medication should be under the guidance of a healthcare professional, as they can determine the appropriate dosage and monitor its effects.
Avoid consumption of alcohol while taking Diretic Tablet as it might make you feel dizzier.
Diretic Tablet is generally not recommended for use in pregnant women. However, consult your doctor before taking it.
Diretic Tablet is generally not recommended for use in breastfeeding women. However, consult your doctor before taking it.
Do not drive or operate any machines if you feel dizzy or unwell after taking Diretic Tablet.
Diretic tablets are to be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.
Diretic Tablets are to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.
Diretic Tablet acts by removing the excess water and certain electrolytes (sodium and chloride) from the body in the form of urine while simultaneously maintaining the levels of potassium in the body.
Oedema is a disorder characterized by an abnormal buildup of fluid in bodily tissues. Diretic Tablet is used to treat edema caused by secondary hyperaldosteronism (excess hormone synthesis by the adrenal gland), chronic congestive cardiac failure (inability of your heart to pump enough blood), and hepatic cirrhosis (liver scarring).
Spironolactone and Furosemide have different mechanisms of action and target different sites in the kidneys. When used together, they have complementary effects and can produce an additive or synergistic diuretic effect.
Furosemide, known as a loop diuretic, acts on the Na+/K+/2Cl- co-transporter in the ascending limb of the Loop of Henle. It inhibits this transporter, blocking the reabsorption of sodium, potassium, and chloride ions. This action leads to increased excretion of sodium and water in the urine, resulting in diuresis. However, the potassium loss caused by Furosemide is a common side effect.
Spironolactone, on the other hand, is a potassium-sparing diuretic that acts at the distal tubule of the nephron. It works by antagonizing the action of aldosterone, a hormone that promotes the reabsorption of sodium in exchange for potassium. By inhibiting aldosterone, spironolactone promotes the excretion of sodium and reduces the excessive loss of potassium caused by Furosemide.
The combination of these two diuretics allows for a more comprehensive and balanced diuretic effect. Furosemide increases the excretion of sodium and water, while spironolactone helps to counterbalance the potassium loss and maintain a more favorable sodium-to-potassium ratio.
Interactions with other medications:
High blood pressure-lowering pills (metoprolol, ramipril, hydrochlorothiazide, atorvastatin): Diretic tablets may interact with these medications used to treat high blood pressure. It can further lower blood pressure, potentially leading to a severe condition. Close monitoring of blood pressure is necessary when using these medications together.
Drug-Food Interaction: Consuming alcohol while taking Diretic Tablet can lead to unpleasant side effects. It is recommended to avoid alcohol to prevent any potential adverse reactions.
Drug-Disease Interactions: Diretic Tablet should not be given to individuals with the following conditions:
It's crucial to consult with a healthcare professional before starting or stopping any medication, as they can provide personalized advice and ensure the safe and effective use of Diretic Tablet based on individual circumstances.
Diretic Tablet should not be used in patients who have anuria (complete absence of urine production), severe renal impairment, rapid deterioration or significant impairment of renal function (creatinine clearance less than 30 ml/min), hyperkalemia (high levels of potassium in the blood), Addison's disease (adrenal gland disorder), or patients who have a known allergy or hypersensitivity to Spironolactone, Furosemide, or sulphonamides.
During pregnancy, the use of Spironolactone should be carefully evaluated, considering the potential risks to both the mother and the fetus. Spironolactone and its metabolites can cross the placental barrier. Animal studies have shown that Furosemide, another component of Diretic Tablet, may cause fetal abnormalities. Therefore, Furosemide should only be used in women of childbearing age when appropriate contraceptive measures are taken, or if the potential benefits outweigh the potential risks to the fetus.
In the case of lactation, metabolites of Spironolactone have been detected in breast milk. If the use of Spironolactone is considered necessary, it is advisable to explore alternative methods of infant feeding. Furosemide is excreted in breast milk, and breastfeeding should be suspended if treatment with Furosemide is deemed necessary.
Diretic Tablet should be avoided in individuals who have a known allergy or hypersensitivity to the medication. It is also contraindicated in individuals with low blood pressure (less than 90 mm Hg), a history of heart attack, kidney disease (with creatinine clearance less than 30 mL/min), liver disease, pregnancy, or those who are planning to become pregnant. Breastfeeding women should also exercise caution as Diretic Tablet can pass into breast milk, although its effects on the baby are not known. It is advisable to inform your doctor if you are taking Diretic Tablet while breastfeeding.
Furthermore, Diretic Tablet should not be used in individuals with low blood pressure (hypotension), cardiogenic shock (sudden reduction in blood flow to the heart), or aortic stenosis (a heart valve problem). Special attention should be given to individuals who rely on their voice for their work, such as actors, singers, or teachers, as Diretic Tablet may cause vocal changes.
Before initiating treatment with Diretic Tablet, it is important to correct any hypovolemia or dehydration, as well as address any electrolyte and acid-base imbalances present in the individual.
Keep below 30°C temperature, absent from light & dampness. Keep out of the reach of children.
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